CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 CONTENTS AGROCHEMICALS CONTRACT SERVICES CORPORATE RESPONSIBILITY COSMETICS & PERSONAL CARE DISTRIBUTION NUTRACEUTICALS LEGENDA WELCOME 2 Exciting times ahead with our new Chemicals Knowledge Hub 4 NEWS SUNRESIN 18 Innovation in Beer Stabilisation METABOLIC HEALTH 24 GLP-1 and the shifting role of supplements: can nutraceuticals keep pace? INTERVIEW The quality assurance team Cerbios-Pharma SA (a HAS company) ROUSSELOT 30 The future of metabolic wellness - How collagen peptides may support glucose control COLLAGEN 34 Collagen’s next chapter: trends, targets, and truths in 2025 INNOVATION & TRENDS 42 The benefits of pharmacy automation 46 GLP-1 analogues market overviewand trends 48 Global pest control management market: Technology analysis 52 Business performance, expectations and top risks: A SOCMA Pulse Poll series initiative (June 2025) CMOS 60 Small batches, big expectations: CMOs adapt to a changing client landscape MATERIAL SCIENCE 62 Industrial coatings: Market overview 64 The rise of water-based barrier coatings 66 The evolution of rubber in automotive manufacturing MATERIAL SCIENCE OILFIELDS & ENERGIES PHARMACEUTICALS REGULATIONS & EHS&S WATER TREATMENT LIFE SCIENCES INTERVIEW Jayashree (Jay) Aiyar Chief Scientific Officer Syngene International Ltd 26 38
2 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 Collaborating for the future with new event partnerships We believe that real connections lead to real progress. That’s why we’re forming partnerships with upcoming industry events, which will allow us to bring you exclusive coverage, updates from expert speakers, and opportunities to network with leaders and innovators from around the world. It’s all about creating a community where ideas can flow, and collaborations can flourish. Looking ahead Our goal is simple: to make knowledge accessible, engaging, and useful for everyone involved in the chemical industry. With fresh content, innovative delivery, and strong partnerships, we’re dedicated to supporting your journey — whether you’re exploring new markets, developing cutting-edge products, or just staying informed. Together, we’re shaping the future of chemicals — smarter, sustainable, and more connected than ever before. ELLIE BRUNI Publishing Director CHEMICALS KNOWLEDGE HUB WELCOME We’re thrilled to introduce a fresh, dynamic way for everyone in the chemicals industry to stay connected — our brand-new Chemicals Knowledge Hub. This isn’t just another publication; it’s a living, breathing platform that updates in real-time, helping you keep pace with the fast-changing world of chemicals. Spotting the big trends in specialty chemicals The specialty chemicals sector is buzzing. From a stronger push toward sustainability and green chemistry to the exciting world of digital tools like AI and data analytics — there’s a lot happening. Companies are innovating more than ever to develop products that are better for the environment and more tailored to specific needs. Our new platform aims to bring clarity to these trends, so you can make smarter decisions and stay ahead of the curve. A new focus on nutraceuticals We’re also excited to expand into the nutraceutical space — a booming area at the intersection of health and chemistry. Our new dedicated section will cover everything from ingredient innovation and regulatory updates to consumer preferences and market growth. Whether you’re a manufacturer, a researcher, or just curious about this fast-moving industry, we want to provide you with insights that matter. Publishing Director: Ellie Bruni | +44 (0) 7872 516194 ellie.bruni@ckh.com Advertising: info@ckh.com Editorial contact: Please send your news and suggestions for feature articles to the editorial team at editor@ckh.com CHEMICALS KNOWLEDGE HUB is published by BIBO Publishing SL, Av. Diagonal, 409, 1St Floor, 08008, Barcelona, Spain. Disclaimer: The disclaimer has an error: BIBO Publishing SL will not be held responsible or liable for errors or omissions supplied or contained in this publication, although due care and attention are taken to ensure all content is accurate at the time of going to press. BIBO Publishing SL also will not be held responsible for any false claims made by advertisers, or in articles contributed by external authors. Copyright: The contents of this publication are copyright © BIBO Publishing SL 2025. No part of this publication can be reproduced or transmitted in any form without the express permission of the publisher. ISSN 2516-4482
4 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 NEWS IMCD Group (‘IMCD’ or the ‘Company’), a global leading partner for the distribution and formulation of speciality chemicals and ingredients, today announces the launch of Glass’Hair Leave-On, a cutting-edge hair care formulation inspired by the trending glass hair look. This leave-on solution from IMCD Beauty & Personal Care is sleek, sensorial and high-performing, capturing the essence of shine and smoothness without compromise. Developed for beauty brands looking to deliver visible results with elegant simplicity, Glass’Hair Leave-On reflects the Company’s unique blend of technical expertise and trend intelligence. Unveiled during a dedicated webcast after a successful preview at in-cosmetics global 2025 in Amsterdam, Glass’Hair Leave-On is the first of ten innovative formulas presented under IMCD’s “Mastering Simplicity” concept. This programme reflects IMCD’s commitment to offering high-performance formulations that are streamlined, sensorial, and built to perform, with no overclaims, just real results. IMCD Beauty & Personal Care is a trusted partner to cosmetics brands and manufacturers worldwide. Backed by the global scale and local know-how of IMCD Group, the business group combines ingredient distribution with advanced formulation development. Its global network of 21 application laboratories, 13 Beauty Studios and 6 Centre of Excellence enables the creation of next-generation beauty products tailored to technical IMCD launches Glass’Hair Leave-On: A high-performance formulation for brands riding the glass hair trend Glass’Hair Leave-On by IMCD (Photo: IMCD) Glass’Hair Leave-On was developed through the IMCD Hair Care & Toiletries Centre of Excellence in Milton Keynes, UK (Photo: IMCD) Mastering Simplicity kit by IMCD (Photo: IMCD)
5 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 NEWS specifications, performance goals, and market trends, all with speed and precision. Formulation meets function, fast Developed through the IMCD Hair Care & Toiletries Centre of Excellence in Milton Keynes, UK, Glass’Hair Leave-On is a prime example of how deep market insight and technical formulation power come together. The result is a ready-to-market concept designed to meet the demand for high shine, smooth texture and modern elegance— delivered quickly, with scalability in mind. From first idea to final texture, the process behind Glass’Hair LeaveOn shows how IMCD helps beauty brands accelerate innovation without compromise. Explore the full “Mastering Simplicity” collection Glass’Hair Leave-On is just the beginning. At in-cosmetics global, IMCD also introduced Fix & Care Hair Stick, a second hair care concept designed for long-lasting hold and definition while preserving a natural hair feel. These two formulations are part of the broader Mastering Simplicity portfolio, created to help brands move faster from brief to breakthrough. “Today’s consumers want hair care that works and feels great without overpromising,” says Laurent Blasco, Global Technical Director, IMCD Beauty & Personal Care. “With Glass’Hair Leave-On we’ve taken a trend and given it backbone, engineering a formulation that delivers on gloss, glide and sensoriality. It’s a formula built to perform, and it’s ready for brands to use now thanks to the speed and precision of our passionate and dedicated experts.” Maud Chapis, Global Marketing Director, IMCD Beauty & Personal Care, adds: “Mastering Simplicity is about letting expertise speak through precision, excellence and innovation. With Glass’Hair Leave-On and the full collection, we’re offering brands a library of smart, trend-driven formulations they can rely on, from ideation to launch. Whether it’s glass hair or next-gen sun care, our teams are ready to support beauty brands in staying relevant, effective, and efficient.” Discover Glass’Hair Leave-On and explore the full “Mastering Simplicity” collection. Watch the webcast replay. Emery Oleochemicals is pleased to announce the appointment of Min Chong as its new Group Chief Executive Officer. Mr. Chong brings to Emery Oleochemicals a distinguished career in the specialty chemicals industry, having held multiple senior leadership roles across the sector. With a proven track record driving strategic growth, operational excellence, and innovation, he is uniquely equipped to lead the company into its next phase of growth and transformation. “We are very pleased to welcome Min to Emery Oleochemicals,” said Peter Hawthorne, Chairman of Emery Oleochemicals’ Board of Directors. “His deep industry expertise, customer focus, and visionary leadership will be instrumental in advancing Emery’s mission, enhancing product and service offerings for our customers, and realizing new growth opportunities for our business and people.” Mr. Chong’s appointment marks an exciting new chapter for Emery Oleochemicals as the company continues to build on its legacy of delivering sustainable, highperformance solutions to customers worldwide. “I am excited to be joining Emery Oleochemicals at such a pivotal moment,” said Min Chong. “I look forward to building on the company›s strong foundation in oleochemicals to drive innovation and deliver exceptional value to our customers and stakeholders.” Emery Oleochemicals appoints Min Chong as Group Chief Executive Officer
6 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 DKSH has announced today that it signed an agreement to acquire Eppendorf’s direct business in Thailand. Eppendorf is a leading international life science company that develops, manufactures, and distributes instruments, consumables, and services for use in laboratories around the world and employs around 4,500 people in more than 30 countries. In Thailand, Eppendorf is a local market leader for liquid handling (pipettes), centrifuges, and general laboratory equipment. The transaction includes the takeover of Eppendorf (Thailand) Co., Ltd. employees, as well as an exclusive right to distribute Eppendorf’s products in Thailand. Through this transaction, DKSH will further solidify its position as a leading market expansion services provider in the field of Scientific Solutions in Asia and beyond. Hanno Elbraechter, Head, Business Unit Technology at DKSH, said: “We are delighted to see Eppendorf Thailand join our operations. This step highlights the continued outsourcing trend adopted by numerous multinational companies aiming to focus more on their strategic core capabilities, that will benefit DKSH. Eppendorf’s portfolio consists of highly competitive instruments, services, and consumables and is complementary to ours in the region. Through our capillary distributor and customer network, we will jointly be able to expand in high-growth segments such as food & beverage, biotech, and pharma.” Wilson Wang, Senior Vice President Asia Pacific China at Eppendorf Group, commented: “We are excited to start this new chapter with DKSH. With this transaction, we are combining the local strengths of DKSH with Eppendorf’s strong brand and premium reliable products. We are confident DKSH will successfully develop the business and are convinced this step is beneficial for our own business, our business partners and customers, as well as our valued employees.” The closing of the transaction is expected during the third quarter of 2025 and is subject to certain conditions. Indovinya, the specialty chemicals division of Indorama Ventures, announces the launch of Food-Grade Kosher&Halal Sorbitan®esters for the food industry. In addition to their widespread use in the cosmetics industry, Sorbitan Esters play a crucial role as emulsifiers in food production, enhancing stability, extending shelf life, and improving both taste and appearance. The ALKEST SP 80 K® and ALKEST SP 60 K® product lines are designed for use in bread, confectionery, oils, dairy, and beverages, offering essential emulsifying and emollient properties that enhance product quality and performance. “We see significant growth potential in the food market as we expand our Sorbitan Esters offering to this sector. These ingredients not only improve the texture and stability of food products but also complement our existing portfolio of food-grade polysorbates,” explains Fabiana Marra, Marketing and R&D Nutrition & Health Director at Indovinya. Beyond meeting the highest standards of quality and safety, ALKEST SP 60 K® is also available in a Non-GMO version, addressing the growing demand for ingredients free from genetically modified organisms. “We take pride in ensuring the highest standards of quality, safety, and compliance on our products. These certifications offer a strategic edge that drives sales, as supermarkets often prioritize brands with these seals. Having Kosher and Halal logos can significantly strengthen a food company’s market positioning,” adds Marra. Indorama Ventures launches food-grade emulsifier NEWS DKSH technology to acquire Eppendorf’s direct presence in Thailand
8 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 NEWS Axplora is proud to unveil a transformative €35 million expansion at its Farmabios site in Gropello Cairoli, Italy, reinforcing the company’s longstanding commitment to serving the evolving needs of its customers through strategic investment and innovation. This latest investment builds on the €45 million already committed over the past five years, bringing Axplora’s total recent investment in Farmabios to over €80 million. The addition of 62,000 square meters of new development in 2026 will more than double the total footprint of the site to 108,000 square meters. This will be more than ten times its original size Farmabios began commercial operations in 1968. “This expansion is not just a matter of scale, it’s about shaping the future of pharmaceutical manufacturing,” said Mario Di Giacomo, Managing Director of Farmabios. “We are investing with purpose: to enhance our capabilities, support our partners, and continue leading with innovation and integrity.” This expansion follows a period of accelerated growth at Farmabios over the last five years, during which €45m has already been invested. Key initiatives include the construction of a new micronisation department, expanded warehouse capacity, and the RS40 building – a state-of-the- art unit purpose-built for the safe and efficient handling of High Potent APIs (HPAPIs). Designed in accordance with the most stringent safety and containment standards, RS40 employs a comprehensive exposure control strategy, including a layout based on exposure zoning that ensures strict segregation of highpotency operations within dedicated suites. The facility supports an Occupational Exposure Limit (OEL) as low as 10 nanograms per cubic meter and complies fully with OEB5 containment criteria. Its design incorporates stand-alone workshops and fully isolated process rooms to mitigate cross-contamination risks, offering maximum protection for both operators and products. In addition, the micronisation rooms are equipped with isolators specifically designed for HPAPI processing, ensuring safe handling of potent compounds at every stage. This period of investment has been matched by significant talent growth: between 2020 and 2024, Farmabios’ workforce nearly doubled, from approximately 150 to nearly 300 employees, reflecting the site’s strategic importance within Axplora’s global network. This trend is likely to continue with the expansion of the site. “The Farmabios site reflects Axplora’s commitment to being a proactive, science-led, and sustainable partner,” said Martin Meeson, CEO of Axplora. “Every investment we make is guided by the ambition to deliver greater value to our customers, while raising the bar in reliability, speed and efficiency.” Building advanced capabilities for a dynamic future Today, Farmabios is equipped with specialized facilities for cytotoxic and sterile processing, comprehensive R&D infrastructure, and robust supply chain and warehousing capabilities. Its environmental performance continues to evolve with the integration of Regenerative Thermal Oxidizers (RTOs), supporting Axplora’s sustainability roadmap. In 2024, these efforts were recognized with Platinum status from EcoVadis, placing the site among the top 1% of companies worldwide for sustainability performance. The new greenfield expansion is designed to support the next generation of pharmaceutical manufacturing – with built-in flexibility, increased production efficiency, and full alignment with global regulatory standards. This milestone represents far more than physical expansion. It signals Axplora’s ongoing momentum as a trusted, innovative, and growthfocused partner to the world’s leading pharmaceutical companies. Building on recent strategic investments of €50 million in Mourenx and €8 million in Le Mans, the Farmabios investment further strengthens Axplora’s manufacturing network. As customer needs evolve, Axplora continues to invest decisively in the capacity, talent, and infrastructure that will define the future of API manufacturing. Axplora announces further €35M expansion at Farmabios to double footprint and fuel long-term growth
10 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 XiMo launches construction of an industrial production for innovative metathesis catalysts Pioneering Olefin Metathesis Technology Finds a New Home in Hungary: XiMo, a global leader in olefin metathesis and a specialist in cutting-edge catalyst development, marked a major milestone with the groundbreaking of its new production facility in the Gödöllõ Innovation and Logistic Park (Gödöllõi Innovációs és Logisztikai Park), just 30 kilometers northeast of Budapest. Backed by a multi-million-Euro investment, the new plant will focus on the large-scale production of XiMo’s innovative metathesis catalysts—technology rooted in Nobel Prize-winning science and central to the company’s core expertise. XiMo’s parent company, Verbio SE, is investing EUR 27.7 million in the project. The investment is supported by a 20 percent subsidy from the Hungarian government amounting to EUR 5.5 million. The plant will bring Nobel Prize-winning technology to an industrial scale, marking a major step toward greener, more sustainable chemical production. Production launch planned for summer 2026 The new facility will enable the large-scale production of advanced catalysts that drive olefin metathesis—a transformative chemical reaction at the heart of greener, more sustainable chemistry. This cutting-edge technology empowers the chemical industry to replace fossil-based feedstocks with renewable, plant-derived alternatives such as rapeseed methyl ester. By enabling the efficient conversion of bio-based raw materials into high-value products—including pheromones for sustainable crop protection, plant-based flavors and fragrances, lubricants, surfactants, and polymers—olefin metathesis plays a vital role in reducing environmental impact and advancing the transition to a circular, lowcarbon economy. “The new plant will enable us to produce molybdenum-, tungsten- and ruthenium-based catalysts on an industrial scale,” says Dr. Levente Ondi, Director of XiMo Hungary Kft. “We expect to begin regular production in summer 2026.” Appreciation and support by the Hungarian government The groundbreaking ceremony at the Gödöllõi Üzleti Industrial Park located – 30 kilometers northeast of Budapest – brought together government officials, company representatives, and business partners to mark the start of construction. Among the distinguished guests were the State Secretary at the Ministery of Foreign Affairs and Trade Mr. Levente Magyar and Mayor of Gödöllõ, Dr. György Gémesi. The Hungarian government emphasized the economic and environmental impact of the new XiMo facility during the groundbreaking ceremony. Verbio SE, the German-based parent company of XiMo, is investing a total of EUR 27.7 million in the construction of the new catalyst production facility. The Hungarian government is supporting the project with a 20 percent subsidy, contributing EUR 5.5 million (HUF 2.2 billion) in public funding. Theodor Niesmann, CTO at Verbio SE, expressed appreciation for the partnership: “On behalf of Verbio, I would like to sincerely thank State Secretary Magyar and the Hungarian government for their ongoing support and trust in our company. Your commitment is deeply valued.” Pioneering green solutions for sustainable chemistry A significant share of the catalysts produced at the Gödöllõi plant will be used by Verbio in its new plant for bio-based chemicals in Bitterfeld, Germany. There, the company is currently building the world’s first Ethenolysis plant to manufacture renewable molecules from rapeseed methyl ester –marking another key milestone in Verbio’s commitment to sustainable innovation. The chemical industry, with its energy-intensive processes and reliance on fossil resources, faces growing pressure to meet ambitious climate targets. Verbio’s renewable chemicals based on XiMo’s innovative catalysts are helping to redefine what is possible. NEWS
11 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 “With this new plant, XiMo enables more innovative technologies converting renewable biomass into high-quality compounds, used in products such as surfactants, lubricants and polymer, without full reliance on fossil resources”, explains XiMo’s Director Dr. Levente Ondi. Nobel Prize-winning technology in practice Amongst the valuable guests was Prof. Dr. Richard Schrock, one of XiMo’s original founders. He was awarded the Nobel Prize in Chemistry in 2005 for his groundbreaking work in the field of metathesis – a key reaction in organic chemistry. His decades of research, together with his colleagues, laid the foundation for the development of molybdenum- and tungsten-based olefin metathesis catalysts. Since XiMo’s acquisition by Verbio SE in 2018, the team led by XiMo’s current Director Dr. Levente Ondi has successfully advanced this technology for industrial application. With the construction of the new production plant in Gödöllõ, these scientific discoveries are now being translated into industrial practice. This marks a significant milestone, opening new possibilities not only for the chemical industry, but also for Verbio’s continued diversification and internationalisation efforts. ACG Engineering, a division of ACG, the world›s only integrated pharmaceutical solutions and manufacturing company, has announced the appointment of Nikhil Kulkarni as the Group CEO of ACG Engineering. Based out of the company’s office in Pune, Nikhil will lead the strategic direction and operations of its engineering division. With over two decades of global leadership experience in the automotive sector, Nikhil brings deep expertise in global product strategy, business development, P&L management, and end-to-end product lifecycle execution. In his new role, he will report directly to Karan Singh, Managing Director of ACG, and will drive innovation aligned with ACG’s mission to create a healthier world. Nikhil’s career spans multiple global markets, including India, the US, Europe, and China, where he has held senior leadership roles at Tata Autocomp Hendrickson Suspension Pvt. Ltd., Minda Corporation Ltd., Faurecia Clean Mobility (FORVIA), and Stoneridge Inc. He has successfully led strategic initiatives across a broad range of technologies and products, including power electronics, emissions systems, safety features, fuel economy solutions, and driver information systems for commercial vehicles, passenger cars, and 2W/3W platforms. An engineer by training, Nikhil holds a Master’s degree in Industrial Engineering from the University of Cincinnati, USA, and a Bachelor’s degree in Production Engineering from Shivaji University, India. He is also a certified Six Sigma Master Black Belt and Design for Six Sigma (DFSS) professional. Commenting on the appointment, Karan Singh, Managing Director at ACG, said: “We are excited to welcome Nikhil to the ACG family. His vast international experience and strong leadership track record make him the ideal choice to steer ACG Engineering into its next phase of growth. His background in the automotive industry adds a unique and valuable perspective that will help us enhance our innovation and deliver sustainable solutions to our customers globally.” Nikhil Kulkarni added: “I am delighted to join ACG at such a pivotal time for the business. I look forward to working with the ACG Engineering and management teams and collaborating with our partners to strengthen our offering and deliver on our commitment to provide access to good medicine and create a healthier world.” ACG strengthens its engineering leadership with appointment of Nikhil Kulkarni as CEO NEWS
Sunresin and ChiralVision expand strategic collaboration to advance immobilized enzyme technologies Sunresin, a global leader in advanced resin technologies, has signed a new agreement with Dutch biocatalysis specialist ChiralVision to provide end-to-end solutions in enzyme immobilization and biocatalytic process development. The agreement strengthens an ongoing collaboration and combines Sunresin’s breadth of resin development and manufacturing capabilities with ChiralVision’s expertise in enzyme immobilization and enzymatic process engineering. Together, the two companies will develop and optimize novel applications using immobilized enzymes as well as offer enhanced support for existing processes. A partnership built for scale and speed By bringing together complementary strengths, Sunresin and ChiralVision are positioned to accelerate the development and commercialization of enzyme-based bioprocesses for their customers, from resin design, functionalization and production through to process development and optimization for specific applications. Customers will benefit from: – Access to a wide range of functionalized resins, including custom-designed supports optimized for specific enzymes and reactions – In-house biocatalyst production, customized for end-user applications – Expert development of robust immobilization processes with high efficiency and recovery – Scalable production of immobilized biocatalysts aligned with end-user specifications A stronger platform for biocatalysis innovation “Working with Rob and the ChiralVision team over the past two decades, I’ve seen first-hand their invaluable knowledge and exceptional dedication to supporting customers,” said Dr. Alessandra Basso, Sales and Marketing Director at Sunresin. “Our expanded partnership reflects the success of numerous collaborative projects over the last two years— from early-stage testing to full-scale implementation. This partnership ensures our customers can access the best immobilized enzyme technologies, and implement them with greater speed, confidence and support.” ChiralVision Managing Director, Rob Schoevaart added: “Our collaboration with Sunresin - one of the world’s leading and most innovative resin manufacturers - enables us to support larger and more complex development projects than ever before, and this partnership significantly strengthens our ability to scale up the commercial production of immobilized enzymes. Working with Alessandra and the Sunresin team brings a deep industry insight, dedication to innovation, and unwavering customer focus that makes them an ideal partner to bring new solutions to the industry.” The reinforced collaboration reflects a shared commitment to driving innovation in green chemistry, biotransformations, and industrial biocatalysis. With an expanding portfolio and proven ability to scale, Sunresin and ChiralVision are setting a new standard for customized, scalable enzyme immobilization solutions. NEWS 12 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025
CONNECTING VOICES OF THE INDUSTRY To stay up to date with the latest news and analysis on biopharmaceutical development & manufacturing, search for ‘24/7 BIOPHARMA’ on Spotify, Apple Podcasts, Google Podcasts and subscribe for free. Michael Quirmbach CEO of CordenPharma Welcome to this episode! We Talked to Michaels Quirmbach CEO of CordenPharma and discussed their ambitious plans and recent strategic moves. Michael will share insights on their record-breaking €1 billion... Mat Minardi EVP of Global Project Management In this episode, we chat with Matt Minardi from Sterling Pharma about what’s really happening in the outsourcing world right now. He shares his thoughts on the current trends, what’s driving change in the industry... Alicia Xaka Associate Director, Business Development - US & Canada, Procos SpA (CBC Group) We’re excited to feature Alicia Xaka, of Procos SpA, a company renowned for its customer-centric approach to custom synthesis and innovative solutions in the...
14 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 WACKER presents new high-consistency silicone rubber for composite insulators NEWS WACKER is all set to unveil a new high-consistency silicone rubber for the production of composite insulators with extruded silicone housing at the next K 2025 International Trade Fair for Plastics and Rubber. The new product is supplied as a 2K addition curing system and is suitable for extrusion manufacturing processes, in particular spiral extrusion. In contrast to other production methods, this makes manufacturing of even large-scale insulators with variable diameters easier and more costeffective. K 2025 will be held in Düsseldorf, Germany, from October 8 to 15. Composite hollow-core insulators come under the category of composite insulators. They are basically made up of a hollow, electrically non-conductive tube with annular insulator housing on the exterior made of an electrically non-conductive material. Hollow core insulators are used for electrotechnical equipment such as bushings, instrument transformers, circuit breakers or surge arresters. They can be imposing in size, especially when it comes to high voltage application. Diameters of over one meter and lengths of over ten meters are not uncommon. But, thanks to their comparatively low weight, composite hollow core insulators are much easier to install than conventional insulators made out of ceramics. Weight savings may add up to 80 percent. At this year’s International Trade Fair for Plastics and Rubber, chemical company WACKER will be presenting a new high-consistency silicone rubber that has been developed specifically for manufacturing composite insulators with extruded silicone housing. This includes especially large volume hollow core insulators. POWERSIL® 1900 A/B can be used to manufacture such components by what is known as the spiral extrusion process. Here, the silicone elastomer is extruded onto a continuously rotating insulating tube, thus ensuring a thoroughly even application of the intricate outer sheds. Thanks to this process, manufacturers can even produce high-precision large-scale insulators at a comparatively low cost. Furthermore, the production of conical shapes – often not feasible with conventional injection-molding techniques – is also possible. WACKER supplies POWERSIL® 1900 A/B as a ready-to-use 2K high consistency silicone rubber. The product cures by addition curing to form an electrically insulating silicone elastomer with excellent resistance to tracking, erosion, and arcing. No byproducts are released during curing. The insulating housing with its sheds has water and dirt-repellent surfaces. Unlike porcelain or glass, they retain their excellent dielectric properties even when used continuously in salty or dusty conditions or exposed to rain and high humidity. Rain and dirty water simply drip off the waterrepellent silicone housing. In most cases, this also eliminates the need for costly cleaning operations of composite insulators. As an elastomer, POWERSIL® 1900 A/B has very good mechanical properties. It is UV-resistant and, thanks to its elasticity, can withstand all kinds of weather, earthquakes and vandalism far better than other materials. Silicone elastomers thus also improve power grid resilience and ensure a secure power supply. Silicones in power engineering Silicone elastomers have been a regular feature in high-voltage engineering for decades. As a highperformance insulating material, they possess numerous properties that no other material can match in this combination. In addition to high tracking, erosion and arc resistance, silicones are extremely resistant to weathering and UV radiation. They can withstand heat, cold and extreme temperature fluctuations. The water-repellent surfaces of the cured elastomer are yet another typical feature of silicone elastomers: they remain water-repellent even when polluted. This property, known in technical jargon as “hydrophobicity” and “hydrophobicity transfer”, prevents the formation of electrically conductive layers of water, dirt and salt, which can lead to electrical failure of the insulator due to flashovers. It is therefore no wonder that silicone elastomers are used today in almost all areas of power transmission and generation.
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17 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 NEWS The Flamma Group (“Flamma”) is a global, fully integrated company producing and commercializing small molecule Active Pharmaceutical Ingredients (APIs) for the life science industry. As a preeminent Contract Development and Manufacturing Organization (CDMO) of New Chemical Entities (NCEs) and late stage intermediates for the Innovator Companies, Flamma celebrated the Grand Opening of its new state-of-the-art cGMP plant in Dalian, China. This milestone aligns with the company’s broader strategy to invest significantly across its global network which included its continued expansion within Italy. “Flamma has been present in the Chinese market for over 30 years. Initially, we focused on sourcing key raw materials directly to secure the supply chain. We then established our own R&D laboratory in China which ultimately led to the formation of Flamma Honkai in Dalian in 2012. We are extremely proud of what we’ve accomplished over the past 17 years of operations in Dalian. With Honkai being a fully owned and run subsidiary, we’ve been able to combine Flamma’s core values and expertise with the efficiency of the Honkai management team, leading to a 30-fold increase in turnover, Chinese FDA approval, and significant market growth,” says Dr. GianPaolo Negrisoli, President and CEO. Founded 75 years ago in Bergamo, Flamma continues to represent the excellence of Italian manufacturing and innovation. “As we inaugurate this major site in Dalian, we also reaffirm our roots,” states GianMarco Negrisoli, Executive Director - Corporate Development. “This global expansion complements the substantial investments we are making in Italy, including significant facility upgrades, capacity increases, and continued recruitment of high caliber talent. Flamma plans to reinvest $200 million worldwide over the next five years to grow our manufacturing capacity, technology and capabilities, reinforcing the synergy between its Italian heritage and global outlook.” The Flamma Group expands globally reinforcing its commitment to growth
18 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 Beer stabilisation is a critical process required in modern brewing to remove undesirable haze formed during storage due to precipitation/aggregation of haze active (HA) compounds. This provides the beer clarity, stability over time and quality. There are different methods that breweries adopt to achieve haze removal such as the use of polyvinylpolypyrrolidone (PVPP), silica gel, enzymes and cold stabilisation to manage haze formation caused by protein-polyphenol complexes. The chromatography approach by using a polyvinyl pyrrolidone (PVP) modified resin allows it to run a very clean, automated process, where the resin remains in a column and can be regenerated efficiently. This article presents an advance in this technology with a PVP functionalised agarose resin used in Controlled Stabilisation Systems (CSS), regenerated for 1,000 cycles and stable to sanitisation. Introduction Beer has played a vital role in human culture for centuries, evolving from a handcrafted beverage to a globally industrialised product influenced by consumer preferences and scientific advancements. Clarity and stability are essential requirements for industrial breweries, allowing for extended shelf and transportation stability, and importantly from a consumer point of view, have a consistent taste and aspect. While haze is integral to certain beer types, such as wheat beers, clarity is often viewed as a sign of freshness and quality1,2. Haze is primarily arising from protein-polyphenol complexes3. Polyphenols and proteins, naturally derived from malt and hops are indispensable to the organoleptic and biochemical properties of beer. The phenolic compounds significantly influence flavour, aroma and stability, and act as natural antioxidants protecting against oxidative damage6. Tannins, a subclass of polyphenols, contribute to the body and mouthfeel of specific beer styles4,5. However, polyphenols also interact with proline containing proteins to form colloidal complexes that lead to haze, a process exacerbated by temperature fluctuations, emphasising the need for effective stabilisation7,8. SUNRESIN An innovation in chromatography for efficient removal of polyphenols in beer stabilisation by combining a novel PVP modified resin in Controlled Stabilisation Systems.
19 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 SUNRESIN Current stabilisation practices focus on reducing haze by targeting its main precursors: polyphenols and proteins. One common method involves using PVPP, an adsorbent with strong affinity for polyphenols. While effective, excessive PVPP can remove beneficial polyphenols critical for flavour and antioxidant properties. Silica-based adsorbents help with protein-induced haze, but lack selectivity and are often used alongside PVPP9. Alternatively, enzymatic stabilisation hydrolyses haze-sensitive proteins, but it may require additional techniques to tackle polyphenol-induced haze effectively10. Chromatographic materials, such as those incorporating cross-linked PVP on engineered supports, have shown promising results in beer stabilisation, with polyphenol adsorption rates reaching 34-55%, and good regeneration properties, offering a sustainable solution for beer stabilisation11. Effective beer stabilisation must balance sensory and functional properties for long-term stability. Over-treatment can deplete essential flavour and antioxidant compounds, while under-treatment may cause colloidal instability. Combining stabilisation techniques with precise brewing process control ensures optimal product quality and extended shelf life12,13. Discussion Sunresin’s innovative PVP-functionalised resin, Seplife® K602FF/CSS3.0, marks a significant advancement in brewing stabilisation technology, offering numerous advantages, including cost savings, scalability, and rapid implementation compared to other PVPP solutions. At its core, Seplife K602FF/CSS3.0 was developed using patented advanced cross-linking and functionalisation technologies14 for optimal performance of the PVP active groups (Figure 1). Sunresin’s methodology created an effective binding matrix for targeting polyphenols in beer, with minimal undesired interactions. Table 1 shows the characteristics of the Seplife K602FF/CSS3.0. The resin appears as perfect spherical beads that can be easily packed in any chromatography system (Figure 2). A contact time of a few seconds is enough to retain beer polyphenols by adsorption, which are then removed from the resin during regeneration. Neither substances are dissolved in the beer nor particles released to the beer during the beer stabilisation treatment. A key performance characteristic of Seplife K602FF/CSS3.0 is its stability for a minimum of 1,000 polyphenol removal cycles, along with the corresponding cleaning-in-place (CIP) and sanitisation steps. Figure 3 shows the results obtained in forced ageing conditions performed using the resin packed in chromatography column treated with commercially available Snow beer (Snowflake Brewing) at a contact time of <1min, followed by 45 min CIP treatment with 1M NaOH after each cycle. The resin maintained its initial polyphenol removal capacity up to the final test. Figure 1. Chemical structure of Seplife® K602FF/CSS3.0. Table 1. The properties of the chromatographic resin Seplife K602FF/CSS3.0. *Test conditions: 26/300mm column, height 20cm, mobile phase: water. Figure 2. Microscope picture of the Seplife K602FF/ CSS3.0 beads.
21 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 over the stabilisation parameters, enhancing the efficiency and effectiveness of the stabilisation process when using Seplife K602FF/CSS3.0. The resin is permanently retained between an inlet and an outlet screen and filtered, unstabilised beer flows through the CSS module. This system has reduced environmental impact due to the small mixed phase volumes and low consumption of water and CIP solution. From an economic point of view, the CSS system due to its module design is characterised by comparatively low investment costs, while the Seplife K602FF/CSS3.0 filling the module is employed for more than 1,000 cycles, without any loss or mechanical damage. At the end of life, the resin is removed from the CSS module and replaced by a fresh one. In comparison, the PVPP is added in 20 to 50g/l and can be regenerated when beer processing exceeds 200,000 hl/year. However, each cycle results in up Stability to sanitisation is another key characteristic of the resin; its stability to 85ºC temperature for 720 hours without change in performance is shown in Figure 4. The total polyphenol content in beer was measured using the Analytica-EBC Method 9.11 Total polyphenols in beer by spectrophotometry. From a regulatory point of view, Seplife K602FF/ CSS3.0 is compliant with Regulation (EC) No 1935/2004 for food-contact materials, ensuring safety and reliability during use. Importantly, Seplife K602FF/CSS3.0 is compatible with the Handtmann Controlled Stabilisation System (CSS). This compatibility extends to different brewing processes, making it suitable for various beer styles and formulations. The typical CSS radial flow columns packed with Seplife K602FF/CSS3.0 are available for installations from 20 hl/h up to 1000 hl/h. Figures 5 and 6 show examples of CSS systems installed and operational at specified breweries. Typically, CSS consists of one or several modules completely filled with the resin and run in a fullyautomated mode, allowing for precise control Figure 5. CSS 200 hl/h German Brewery. Figure 6. CSS 3x 300 hl Contiflow Australian Brewery. Figure 4. Effect of sanitization time at 85ºC on the polyphenol removal from commercially available Snow beer. Figure 3. Representation of the polyphenol removal from commercial Snow beer during forced ageing test including CIP with 1M NaOH. SUNRESIN
22 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 SIMONA SERBAN Global Life Science Applications Director Sunresin SUNRESIN MICHAEL FEISCHEb, MARC PFEILSTICKERb, XIAOKANG KOUa, LONG LIUa, XIAOJU LEIa, YALI TANa, FRANK GALBRECHTa, ALESSANDRA BASSOa aSunresin New Materials Co. Ltd bAlbert Handtmann Armaturenfabrik GmbH & Co. KG to 3% PVPP loss with some PVPP particles being retrieved in the beer as microplastic. This highlights that CSS system combined with Seplife K602FF/CSS3.0 resin provides a cost effective, reliable and consistent technology, in line with the modern quality and safety requirements of the beer industry. Conclusion Sunresin’s Seplife K602FF/CSS3.0 resin is specifically designed for polyphenol removal in beer, addressing the evolving needs of the modern brewing industry. It exhibits excellent chemical and physical stability in accelerated ageing tests and is well-suited for use in CSS systems. It is commercially available from Handtmann in batch size 300-1000L with a short delivery time. Seplife K602FF/CSS3.0 is compliant with food regulations and can be safely used without risks of leaching or contamination. Technical support will facilitate installation of resin in any equipment for easy product employability. The combination of Seplife K602FF/CSS3.0 and CSS systems offers advantages in terms of quality, scalability, food compliance and economical savings thanks to high automation and continuous processing. References 1. Bamforth CW. 125th Anniversary Review: The Non-Biological Instability of Beer. Journal of the Institute of Brewing 2011;117(4):488–97. 2. Vanderhaegen B, Neven H, Verachtert H, Derdelinckx G. The chemistry of beer aging – a critical review. Food Chemistry 2006;95(3):357–81. 3. Jongberg S, Andersen ML, Lund MN. Characterisation of protein-polyphenol interactions in beer during forced aging: Protein-polyphenol interactions in beer haze. J Inst Brew 2020;(126):371–81. 4. Carvalho DO, Guido LF. A review on the fate of phenolic compounds during malting and brewing: Technological strategies and beer styles. Food Chemistry 2022;372:131093. 5. Šibalić D, Planinić M, Jurić A, Bucić-Kojić A, Tišma M. Analysis of phenolic compounds in beer: from raw materials to the final product. Chem Pap 2021;75(1):67–76. 6. Habschied K, Loncarić A, Mastanjević K. Screening of Polyphenols and Antioxidative Activity in Industrial Beers. Foods 2020;9(2):238. 7. Leiper KA, Miedl M. Colloidal stability of beer. ˇ In: Beer. Elsevier; 2009. p. 111–61. 8. Eastmond R, Gardner RJ. Effect of Various Polyphenols on the Rate of Haze Formation in Beer. Journal of the Institute of Brewing 1974;80(2):192–200. 9. Bamforth CW. Beer Haze. Journal of the American Society of Brewing Chemists 1999;57(3):81–90. 10. Cimini A, Moresi M. Towards a Kieselguhrc and PVPPcFree Clarification and Stabilisation Process of Rough Beer at RoomcTemperature Conditions. Journal of Food Science 2018;83(1):129–37. 11. Maloisel J-L, Sondermann T, Lind O. Stabilisation of fermented beverages. 2016;(Patent: WO 2015/080657 Al):29. 12. Mastanjević K, Krstanović V, Lukinac J, Jukić M, Vulin Z, Mastanjević K. Beer–The Importance of Colloidal Stability (Non-Biological Haze). Fermentation 2018;4(4):91. 13. Mitchell AE, Hong Y-J, May JC, Wright CA, Bamforth CW. A Comparison of Polyvinylpolypyrrolidone (PVPP), Silica Xerogel and a Polyvinylpyrrolidone (PVP)- Silica Co-Product for Their Ability to Remove Polyphenols from Beer. Journal of the Institute of Brewing 2005;111(1):20–5. 14. Li C, Li Y, Liu L, Wang K, Wang M. A chromatography medium for removing polyphenols and a preparation method thereof. 2024; (Patent: CN117772162A):6. ˇ ˇ ˇ
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24 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 Interest in glucagon-like peptide-1 (GLP-1) receptor agonists has never been higher with these medications hailed for their appetitesuppressing effects and subsequent weight loss in users. This year’s Vitafoods Europe has given a unique insight into the efforts made by the nutraceutical industry to adapt and innovate in response to the surge in popularity and increased awareness about metabolic health. “As GLP-1 agonists continue to revolutionize weight management and metabolic health, this category is also generating new opportunities in the supplement space,” said Stratum Nutrition, a US-based ingredients supplier, who were at Vitafoods showcasing products that support the needs of GLP-1 users. “Since the effectiveness of GLP-1 agonists can be tempered by common side effects and metabolic challenges, this creates a timely opening for finished product formulators to develop targeted products that complement these therapies and improve the users’ experience.” GLP-1’s significance GLP-1 is a hormone that plays a crucial role in regulating blood sugar levels and appetite. GLP-1 receptor agonists mimic this hormone, enhancing insulin secretion, slowing gastric emptying, and promoting satiety. The effectiveness of these drugs in weight management has led to increased consumer awareness and interest in GLP-1 pathways. Industry response Amid the surge in popularity of GLP-1 medications like semaglutide, the nutraceutical industry is looking to carve out a complementary role, offering products that nutritionally support consumers on these therapies or those seeking natural alternatives. By focusing on ingredients that may stimulate endogenous GLP-1 release or improve satiety, blood sugar control, and gut health, supplements can help reinforce the lifestyle changes often recommended alongside GLP-1 treatments. Spotlight on key ingredients This mindset was evident at this year’s Vitafoods, where ingredient suppliers positioned their offerings as natural, scientifically-validated complements to pharmaceutical interventions, while tapping into an expanding market focused on weight management and glucose control. Among the standout players was Rousselot and its newly launched Nextida platform of specific collagen peptide compositions. It’s Nextida GC is a formulation developed to support glucose control by naturally stimulating GLP-1 secretion. METABOLIC HEALTH
25 CHEMICALS KNOWLEDGE HUB Issue 1 / July 2025 METABOLIC HEALTH “As consumer awareness of glucose management and GLP-1 increases, we are excited to present Nextida GC with new clinical data in Barcelona,” said Florencia Moreno Torres, Global Marketing Manager Health & Nutrition at Rousselot. “Nextida GC offers a unique approach in the nutraceutical space to help brands address the evolving metabolic health market, the natural way.” Nextida GC, the first ingredient from Rousselot’s Nextida platform of specific collagen compositions, is designed to maintain balanced post-meals glucose levels in healthy individuals by leveraging the body’s natural GLP-1 response. In pre-clinical and clinical studies, Nextida GC demonstrated its ability to enhance the body’s glucose regulation mechanism, also slowing down the gastric emptying process. Glucose control is important to avoid destabilizing sugar crashes and potentially their associated consequences such as cravings, overeating and fatigue. Other exhibitors in the GLP-1 space included Nexira, who showcased its GLP-1 Collection, featuring ingredients like Carolean, an extract derived from cactus, and VinOgrape, a grapederived polyphenol. Formulation considerations While the promise is there, the process of formulating supplements that support GLP-1 pathways presents a number of unique issues. Whilst regulatory bodies have warned against stating direct comparisons between supplements and pharmaceutical drugs, laws to enforce this remain inconsistent. In the US, the FDA do not regulate dietary supplements for safety or effectiveness before they enter the market. Meanwhile, in Europe the European Commission and national food safety authorities such as EFSA, FSA and BfR monitor and enforce legislation on products that reference GLP-1, ensuring that they are worded to avoid implying a medicinal function unless the product is registered as a medicine. In a landmark case in April of this year, wellness brand Lemme Inc. was accused of misleading marketing practices related to its GLP-1 Daily supplement. The class action complaint highlighted a lack of “clinical data that supports the notion that simply boosting the amount of naturally occurring GLP-1 in the body has sustained weight loss effects.” A spokesperson for Lemme told Bloomberg Law, the lawsuit was ‘frivolous’. Metabolic health strategy This legal challenge serves to underline the growing scrutiny facing brands in the metabolic health space, particularly as consumer expectations rise alongside scientific awareness. As the sector moves beyond quick-fix claims, a long-term strategy grounded in credible science and lifestyle support is taking shape. As David Despain, senior principal nutritionist at Nestlé Health and Science, noted at Vitafoods Europe 2025, “any tools that can help with simply helping people ease into longterm diet and lifestyle changes is still a fantastic opportunity for this industry.” WILL CHU Editorial team CHEMICALS KNOWLEDGE HUB
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