Following the completion of its $64 billion takeover of Shire, Japanese pharma company Takeda has announced plans to restructure its US operations. In a first move, it will close its Chicago-area headquarters at Deerfield, Illinois, and concentrate the activities close to Boston, near the former headquarters of Ariad, a biotech it acquired for $5.2 billion in 2017.

About 1,000 employees will be affected by the move. Some will receive relocation offers, Takeda told US trade journal Fierce Pharma.

The plans, which the company said would better position its pipeline and simplify its US operations, are subject to regulatory and shareholder approvals. Shire also has a base in the Boston area, where it employs 3,000 people. Takeda employs more than 5,000 people in the US.