Last year Honeywell established a collaboration with FreeThink Technologies, a specialist in the science and technology of stability studies, to add FreeThink’s predictive shelf life modeling to its existing suite of Healthcare Packaging services, combining Honeywell’s expertise in managing thermoformable, moisture barrier film with FreeThink Technologies’ know-how of chemical and physical stability and accelerated shelf-life modeling for a wide range of products, including medicines. The pharmaceutical and related industries can benefit from the alliance through selecting the optimal blister packaging, including, where appropriate, the suitable grade of Aclar film for solid oral drugs based upon accelerated degradation data, comprehensive kinetic modeling and robust statistical analysis carried out by FreeThink Technologies. Honeywell and FreeThink’s combined service offering now supports pharmaceutical customers, including originator, generics, OTC and adjacent industries in all phases of development with an accurate model for a product’s shelf-life and stability in as little as four weeks.
Improved packaging: Aclar films
Honeywell’s Healthcare Packaging business includes the production of Aclar and Aclar Accel barrier films, which help pharmaceutical packaging companies lower total packaging costs, improve the flexibility of operations, and increase overall profitability. Aclar
films are based on polychlorotrifluoroethylene (PCTFE) fluoropolymer technology. They are crystal clear, biochemically inert, chemical-resistant, nonflammable, and plasticizer- and stabilizer-free. The films can facilitate increased patient compliance with doctor prescriptions with see-through, portable and patient-friendly pack presentations. Aclar thermoformable films are used in a broad range of markets including originator and generic pharmaceuticals, and OTC pharmaceutical and animal health packaging.
In comparison to packages made of cold form foil, Aclar enables smaller blister pack sizes that reduce shelf space and usage of raw materials, and lower transport costs. Available in many thickness grades and a wide range of moisture barriers, Aclar provides flexibility for pharmaceutical companies to optimize moisture protection for medicines across different climate conditions.
Modelling shelf life and stability
Honeywell says its partnership with Freethink will enable its customers to select the optimal blister packaging, including where appropriate, the suitable grade of Aclar film for solid oral drugs based upon accelerated degradation data, comprehensive kinetic modelling and robust statistical analysis carried out by FreeThink Technologies. The combined service will support pharmaceutical customers, including originator, generics, OTC and adjacent industries, in all phases of development with an accurate model for a product’s shelf-life and stability in time periods as short as four weeks. The company says the collaboration will provide its customers with reduced packaging cost, shorter time to market and greater confidence when making primary packaging decisions.
FreeThink’s predictive modeling service was founded on the peer-reviewed and widely adopted Accelerated Stability Assessment Program (ASAP) which provides credible product expiration dating based on confidence levels derived from experimental design and statistical data analysis, while the company’s laboratories apply their extensive expertise in rapid product shelf-life determination with the proprietary software, ASAPprime, which provides statistical modelling from experimental data.
Market expansion: conforming to different regulations
Aclar and Aclar Accel barrier films: helping pharmaceutical packaging companies lower total packaging costs, improve their flexibility of operations, and increase their overall profitability.
(Photo: Honeywell Healthcare Packaging)